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In the present study, to extend the idea of mature adipocyte proliferation and to elucidate its possible contribution to the development of adipose tissues, we analyzed both brown and beige adipose tissue, and the induction of beige adipocytes, using adipocyte-specific p27-over-expressing mice.To investigate whether the inhibition of cell-cycle progression in mature adipocytes affects the development of adipose tissue, transgenic (Tg) mice expressing p27 under the control of the adipocyte-specific a P2 promoter were generated.I've been a fan of Japanese popular music for over 35 years, and have managed to collect hundreds of CDs during that time.
We previously reported brown adipocytes can proliferate even after differentiation.
To test the involvement of mature adipocyte proliferation in cell number control in fat tissue, we generated transgenic (Tg) mice over-expressing cell-cycle inhibitory protein p27 specifically in adipocytes, using the a P2 promoter.
However, it has been repeatedly suggested that proliferation of mature adipocytes may also be involved in adipose tissue hyperplasia.
During WAT hyperplasia, isotope-labeled thymidine was incorporated not only into the preadipocyte fraction, but also, into the mature adipocyte fraction.
In this regard, DNA content per the whole tissue in the BAT of Tg mice was significantly lower than in WT mice (Fig. The m RNA expression levels of several genes related to BAT thermogenic function (that is, Ucp1, Cox IV Cide-a, Pgc-1a, and Dio2) in Tg mice were comparable to those in WT mice (Fig. Consistent with the m RNA expression data, thermogenic UCP1 levels per mg protein in Tg mice were similar to those in WT mice (Fig. However, the total amount of UCP1 per the whole tissue was only 27.5% of that measured in WT mice (Fig.
2C), presumably because of the reduced number of brown adipocytes.a P2-p27 transgenic mice had a lower amount of UCP1 and an attenuated thermogenic response to cold exposure or β3-AR agonism.
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As neither cell size nor the lipid content in brown adipocytes differed between WT and Tg mice (Fig.
1D), the smaller amount of BAT in Tg mice could be due to a reduction in the number of adipocytes.
p27 prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes by binding to the complex, resulting in the inhibition of cell-cycle progression during the G1 phase.Tags: Adult Dating, affair dating, sex dating